在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

FDFT1 Antibody

  • 中文名稱:
    FDFT1兔多克隆抗體
  • 貨號:
    CSB-PA008562LA01HU
  • 規(guī)格:
    ¥440
  • 圖片:
    • Western Blot
      Positive WB detected in: HepG2 whole cell lysate, SH-SY5Y whole cell lysate, HEK293 whole cell lysate
      All lanes: FDFT1 antibody at 3µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 49, 41, 39, 36, 44 kDa
      Observed band size: 49 kDa
    • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA008562LA01HU at dilution of 1:100
    • Immunofluorescent analysis of HepG2 cells using CSB-PA008562LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) FDFT1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    FDFT1
  • 別名:
    DGPT antibody; ERG9 antibody; Farnesyl diphosphate farnesyltransferase antibody; Farnesyl-diphosphate farnesyltransferase antibody; FDFT_HUMAN antibody; FDFT1 antibody; FPP:FPP farnesyltransferase antibody; SQS antibody; Squalene synthase antibody; Squalene synthetase antibody; SS antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Squalene synthase protein (2-417AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產(chǎn)品,F(xiàn)DFT1 Antibody (CSB-PA008562LA01HU),的標記方式是Non-conjugated。對于FDFT1 Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產(chǎn)品名稱 應用
    HRP CSB-PA008562LB01HU FDFT1 Antibody, HRP conjugated ELISA
    FITC CSB-PA008562LC01HU FDFT1 Antibody, FITC conjugated
    Biotin CSB-PA008562LD01HU FDFT1 Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB, IHC, IF
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene. Proceeds in two distinct steps. In the first half-reaction, two molecules of FPP react to form the stable presqualene diphosphate intermediate (PSQPP), with concomitant release of a proton and a molecule of inorganic diphosphate. In the second half-reaction, PSQPP undergoes heterolysis, isomerization, and reduction with NADPH or NADH to form squalene. It is the first committed enzyme of the sterol biosynthesis pathway.
  • 基因功能參考文獻:
    1. The results indicate that the ennea-peptide CLSPHSMFC, tetra-peptides SMFC, CKTE, and WHQW can effectively inhibit Squalene Synthase activities (IC50 values equal to 64, 76, 87, and 90 muM, respectively) PMID: 26922723
    2. The minor allele in FDFT1 was associated with advanced fibrosis in the non-steatotic but not in the steatotic subgroup in patients with chronic hepatitis C. PMID: 23870067
    3. Up-regulation of SQS promotes metastasis of lung cancer by enhancing tumor necrosis factor-alpha receptor 1 and nuclear factor-kappaB activation and matrix metallopeptidase 1 expression. PMID: 25152164
    4. Several critical residues that are involved in binding of NADPH have been identified in the active site of squalene synthase. PMID: 24531458
    5. HCV infection increases FDFT1 protein level but not FDFT1 mRNA level. PMID: 24690320
    6. this finding yields a new method of colorimetric screening for the cellular activity of squalene synthases, which are major targets for cholesterol-lowering drugs. PMID: 24333579
    7. ABHD5, PGRMC1 and SQS are novel markers for sebaceous carcinoma and can reliably distinguish sebaceous neoplasms from non-sebaceous tumors, specifically BCC with clear cell features. PMID: 23557589
    8. FDFT1 and its encoded enzyme, squalene synthase, may play an important role in prostate cancer development and its aggressive phenotypes. PMID: 22546838
    9. CTSB and FDFT1 are excluded as candidates for keratolytic winter erythema PMID: 21945151
    10. NASH is intimately related to fibrosis progression, the FDFT1 SNP is a good candidate for a link with inflammation and fibrosis. PMID: 21439984
    11. In multivariate models adjusted for age, body mass index, diabetes, waist/hip ratios, and levels of glycated hemoglobin, the NAFLD activity score was associated with the SNP rs2645424 on chromosome 8 in farnesyl diphosphate farnesyl transferase 1 (FDFT1) PMID: 20708005
    12. Results report the high-resolution x-ray structures of human farnesyl pyrophosphate synthase in complexes with risedronate and zoledronate, two of the leading nitrogen-containing bisphosphonates in clinical use. PMID: 16684881
    13. in prostate cancer cells SQS expression is enhanced by androgens, channeling intermediates of the mevalonate/isoprenoid pathway toward cholesterol synthesis PMID: 17483544
    14. lysine in codon 45 is conserved across 11 mammals and lies in an exonic splicing enhancer site, suggesting this coding variant in the squalene synthase gene influences plasma cholesterol levels, by affecting the intracellular production of cholesterol PMID: 18350552
    15. the liver X receptor alpha directly silencing the expression of two key cholesterologenic enzymes (lanosterol 14alpha-demethylase (CYP51A1), and squalene synthase (farnesyl diphosphate farnesyl transferase 1)) via novel negative LXR DNA response elements PMID: 18676367
    16. squalene synthase may be involved in the etiology of hypercholesterolemia PMID: 19054015
    17. FDFT1 rs7001819 showed no association with obesity, neither when analysing quantitative traits nor when performing case-control studies of obesity PMID: 19245693

    顯示更多

    收起更多

  • 亞細胞定位:
    Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Phytoene/squalene synthase family
  • 組織特異性:
    Widely expressed.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 3629

    OMIM: 184420

    KEGG: hsa:2222

    STRING: 9606.ENSP00000220584

    UniGene: Hs.593928



主站蜘蛛池模板: 少妇乳大丰满在线播放| 亚洲国产av无码精品| 久久久精品国产免大香伊| 国产精品久久久久久吹潮| 国产好爽…又高潮了毛片| 国产亚洲精品第一综合不卡| 亚洲丁香五月激情综合| 无码国产成人久久| 国产偷窥熟女精品视频大全| 免费精品国产人妻国语| 性无码免费一区二区三区在线| 好男人www社区视频在线资源| 亚洲人成无码网站在线观看| 成人美女黄网站色大免费的| 国产午夜视频在线观看| 精品三级av无码一区| 欧洲熟妇色xxxxx视频| 丝袜熟女国偷自产中文字幕亚洲| 日日噜噜夜夜狠狠va视频| 人妻无码人妻有码中文字幕| 无码国产精品一区二区免费虚拟vr| 成在线人av无码高潮喷水| 国产成人亚洲精品无码青青草原 | 狠狠色狠狠色综合网老熟女| 97久久超碰中文字幕| 国产一区二区三区乱码| 久久99国产精品成人| 国产日韩在线视看高清视频手机 | 亚洲色成人一区二区三区小说| 精品无码欧美黑人又粗又| 亚洲精品无码中文久久字幕| 亚洲国产精品自产在线播放| 久无码久无码av无码| 18禁真人抽搐一进一出在线| 欲女熟妇国产一区二区| 国产乱人伦无无码视频试看| 亚洲日本va午夜在线电影| 人人妻人人澡人人爽人人精品97| 在线亚洲中文精品第1页| 欧美老熟妇欲乱高清视频| 亚洲一区二区无码偷拍|